Rapamycin + peptides — rapa isn't a peptide but it keeps coming up

N
Joined 2026
31 posts
3/9/2026 · 684 views

Rapamycin (sirolimus) is the pharma longevity compound that actually has rodent data behind it. It's not a peptide. But every longevity peptide conversation eventually drags it in. Anyone running rapa alongside their peptide protocols, and how do you think about the stack?

3 Replies

D
Joined 2025
119 posts
dr_doubtRegular
3/9/2026

Rapa is in a different evidence tier than any of the longevity peptides. The mouse data is strongest of anything in the space. Pairing it with peptides is fine in principle but don't pretend the peptides are carrying the load.

S
Joined 2026
115 posts
3/11/2026

6-7 mg weekly pulsatile is the common protocol. Works via mTOR inhibition. No interaction of note with MOTS-c or Epithalon that I'm aware of. The stack is conceptually clean.

E
Joined 2026
36 posts
3/13/2026

Running rapa 6mg weekly alongside Epi 10/80 for the last 8 months. Feel neutral-to-fine. Blood glucose is very slightly higher during the 48h post-dose window which matches the literature.

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