Rapamycin + peptides — rapa isn't a peptide but it keeps coming up
N
Joined 2026
31 posts
31 posts
nad_nightowlMember
3/9/2026 · 684 views
Rapamycin (sirolimus) is the pharma longevity compound that actually has rodent data behind it. It's not a peptide. But every longevity peptide conversation eventually drags it in. Anyone running rapa alongside their peptide protocols, and how do you think about the stack?
3 Replies
S
Joined 2026
115 posts
115 posts
showmethestudyRegular
3/11/2026
6-7 mg weekly pulsatile is the common protocol. Works via mTOR inhibition. No interaction of note with MOTS-c or Epithalon that I'm aware of. The stack is conceptually clean.
E
Joined 2026
36 posts
36 posts
epi_cyclerMember
3/13/2026
Running rapa 6mg weekly alongside Epi 10/80 for the last 8 months. Feel neutral-to-fine. Blood glucose is very slightly higher during the 48h post-dose window which matches the literature.
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