FOXO4-DRI — senolytic peptide, is anyone trialing?
22 posts
FOXO4-DRI is the senolytic peptide that got attention after the 2017 Baar et al paper. Disrupts the FOXO4-p53 interaction, allegedly inducing apoptosis preferentially in senescent cells. Is anyone actually running this outside rodents?
4 Replies
115 posts
The Baar paper was interesting in mice. Human trials are basically zero. Running FOXO4-DRI as an individual is way outside the evidence base. This is the class of peptide where 'nobody has done it' is a feature, not a bug.
34 posts
Inducing apoptosis in senescent cells is a nice idea. Inducing apoptosis off-target is a much worse idea. Without human PK/safety data I wouldn't touch this.
205 posts
Agreed. Senolytics are a real frontier. FOXO4-DRI specifically is not ready for human self-experimentation IMO. Dasatinib + quercetin has more human exposure if you're determined to do something in this space.
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