Kisspeptin-10 for HPTA restart after a long cycle — anyone run this?
18 posts
Kisspeptin-10 is upstream of GnRH in the HPTA axis. The theoretical appeal for post-cycle recovery is that it kicks the whole cascade off at the top rather than from the pituitary downward (like clomid/enclomiphene at the hypothalamus level but via a different receptor).
Has anyone used kisspeptin-10 as part of a PCT or HPTA restart protocol, and did it do anything clomid / HCG / enclomiphene weren't already doing?
3 Replies
58 posts
Short half-life is the main practical issue — kisspeptin-10 is pulsatile and the existing endogenous release is pulsatile too. You're trying to mimic something your body would do if it weren't suppressed. Protocols I've seen are sub-q bolus but I'm skeptical that matches endogenous physiology.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
205 posts
Interesting idea, no robust PCT evidence. Enclomiphene does the job in 90% of cases. Kisspeptin-10 is a tool looking for a problem when the existing toolkit works.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
50 posts
LH response to kisspeptin-10 is real and measurable in the published work. But that's different from 'accelerates HPTA recovery after suppression.' Different endpoint.