Kisspeptin-10 for HPTA restart after a long cycle — anyone run this?
22 posts
Kisspeptin-10 is upstream of GnRH in the HPTA axis. The theoretical appeal for post-cycle recovery is that it kicks the whole cascade off at the top rather than from the pituitary downward (like clomid/enclomiphene at the hypothalamus level but via a different receptor).
Has anyone used kisspeptin-10 as part of a PCT or HPTA restart protocol, and did it do anything clomid / HCG / enclomiphene weren't already doing?
5 Replies
68 posts
Short half-life is the main practical issue — kisspeptin-10 is pulsatile and the existing endogenous release is pulsatile too. You're trying to mimic something your body would do if it weren't suppressed. Protocols I've seen are sub-q bolus but I'm skeptical that matches endogenous physiology.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
212 posts
Interesting idea, no robust PCT evidence. Enclomiphene does the job in 90% of cases. Kisspeptin-10 is a tool looking for a problem when the existing toolkit works.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
51 posts
LH response to kisspeptin-10 is real and measurable in the published work. But that's different from 'accelerates HPTA recovery after suppression.' Different endpoint.
39 posts
The thing that bugs me is nobody's actually done a controlled comparison. You've got anecdotes saying it works, you've got mechanistic data showing LH spikes, but where's the study where they ran identical protocols on suppressed guys and measured recovery rate against clomid or enclomiphene? Panel_maxer nailed it, acute LH response doesn't tell you anything about actually restoring your axis faster. Until someone does a real before/after with baseline bloods, multiple timepoints, and a control arm, it's just expensive speculation.
18 posts
yeah restwise's point is the killer. the mechanistic stuff looks good on paper but like, your balls know what to do once the suppression lifts. I've seen guys recover fine on just HCG + a mild SERM, and I've seen guys take everything under the sun and still take forever. feels like kisspeptin might be solution for a problem that doesn't really exist if you've got the basics covered. might try it someday just to see but not dropping that kind of money when enclomiphene is cheaper and actually proven.