Follistatin / FS-344 — is anyone really using this for hypertrophy?

F
Joined 2026
24 posts
1/16/2026 · 476 views

Follistatin gene therapy (AAV-FS344) has been floated in research for muscular dystrophy. The peptide analogs sold in the gray market are different things and the 'follistatin 344' vials out there are almost certainly not the gene therapy.

Anyone actually running peptide follistatin and seeing anything? My guess is the answer is 'no, it's a branding exercise' but I'm open to being corrected.

5 Replies

D
Joined 2025
122 posts
dr_doubtRegular
1/17/2026

The gene therapy is not the peptide. The peptide bioavailability is poor even if purity is good. 'FS-344' sold as a peptide is closer to a marketing SKU than a real research tool.

T
Joined 2025
68 posts
theoreticRegular
1/18/2026

Myostatin inhibition via peptide follistatin in humans: no good evidence. Real myostatin inhibitors that have shown muscle gain are all biologics in clinical trials, not this.

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R
Joined 2026
43 posts
1/24/2026

Ran a full cycle of gray-market 'follistatin' and noticed nothing beyond the training gains I'd expect anyway. Waste of money for me.

W
Joined 2026
24 posts
4/23/2026

Yeah I'm gonna agree with the consensus here. Tried it for like 8 weeks subq and honestly couldn't tell if it was doing anything or just my training getting dialed in. The peptide version is probably so degraded by the time it hits your system that it's not worth the hassle. If you actually want myostatin inhibition there's better stuff in trials but that's different conversation entirely.

K
Joined 2025
16 posts
4/27/2026

Everyone here is right. The peptide version is garbage and the gene therapy isn't something you can just buy. If you're actually looking to mess with myostatin there's way better stuff that's at least real, but most people don't even know what they're injecting anyway so follistatin vials will keep selling forever. Skip it.

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