MOTS-c dose debates — 10mg weekly vs 5mg 2x week vs daily microdose
32 posts
MOTS-c is a mitochondrial-derived peptide with metabolic and exercise-mimetic claims. Protocols vary wildly:
- 10mg once a week (the 'pulse' school)
- 5mg twice a week (the 'split' school)
- 1–2mg daily (the 'microdose' school)
Half-life is modest (~5 hours from what I can find) which argues against once-weekly, but the downstream metabolic effects might be longer-acting than serum presence suggests.
Anyone with measurable metabolic changes on one of these and not the others?
4 Replies
33 posts
Ran 5mg 2x weekly for 12 weeks. HbA1c moved from 5.4 to 5.2, fasting insulin from 8 to 6. Can't isolate from my training changes in the same period. Possibly real, possibly noise.
58 posts
The mitochondrial biogenesis pathway is more about chronic signaling than peak concentration. Daily microdose has a theoretical argument but the cost is higher. I think split twice-weekly is the pragmatic compromise.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
36 posts
Pulse (10mg weekly) worked fine for me subjectively. The short half-life argument assumes effects track serum concentration, which for pathway-activating peptides isn't always true.
31 posts
Stacking MOTS-c with NAD+ precursors is trendy. I don't see a good mechanistic argument for synergy beyond 'both are mitochondrial.' Haven't tested directly.