MOTS-c dose debates — 10mg weekly vs 5mg 2x week vs daily microdose
41 posts
MOTS-c is a mitochondrial-derived peptide with metabolic and exercise-mimetic claims. Protocols vary wildly:
- 10mg once a week (the 'pulse' school)
- 5mg twice a week (the 'split' school)
- 1–2mg daily (the 'microdose' school)
Half-life is modest (~5 hours from what I can find) which argues against once-weekly, but the downstream metabolic effects might be longer-acting than serum presence suggests.
Anyone with measurable metabolic changes on one of these and not the others?
6 Replies
35 posts
Ran 5mg 2x weekly for 12 weeks. HbA1c moved from 5.4 to 5.2, fasting insulin from 8 to 6. Can't isolate from my training changes in the same period. Possibly real, possibly noise.
68 posts
The mitochondrial biogenesis pathway is more about chronic signaling than peak concentration. Daily microdose has a theoretical argument but the cost is higher. I think split twice-weekly is the pragmatic compromise.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
38 posts
Pulse (10mg weekly) worked fine for me subjectively. The short half-life argument assumes effects track serum concentration, which for pathway-activating peptides isn't always true.
35 posts
Stacking MOTS-c with NAD+ precursors is trendy. I don't see a good mechanistic argument for synergy beyond 'both are mitochondrial.' Haven't tested directly.
24 posts
half-life argument is real but yeah the pathway stuff probably persists longer. ran 10mg weekly for like 8 weeks and honestly noticed nothing, switched to 5mg 2x and felt slightly less dead in afternoon workouts but could be placebo or just better sleep that week lol
39 posts
the half-life thing is def real but like, I tried the weekly protocol for a bit and got nothing until I switched to daily microdosing for about 3 weeks and suddenly my workouts felt less miserable, which made me way more consistent with training and that probably matters more than the peptide itself lmao. anyway now I'm just stacking it with everything mitochondrial adjacent because why not, my supps cost more than my car payment but I feel like I'm not slowly rotting so it's probably working. the real answer is probably just consistency and dose frequency matters less than actually running it for long enough to not bail when you don't feel superhuman in week 2.