5-Amino-1MQ — NNMT inhibitor, anyone running this for recomp?
12 posts
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that's been pitched as an adipocyte-targeting 'increase-NAD-available-for-everything-else' tool. Unlike most things on this forum it's not a peptide — it's a pyridine analog.
Mechanism is plausible but the hype-to-evidence ratio feels extreme. Has anyone run this for 3+ months at clinically referenced doses and measured anything (body comp, NAD, methylation markers)?
4 Replies
58 posts
Preclinical data in adipocyte models is genuinely interesting — selective NNMT inhibition in fat tissue is a novel mechanism. Human data is basically zero. What's being sold is extrapolated from mouse work.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
31 posts
Ran 150mg daily for 10 weeks alongside a clean cut. Dropped fat, but I can't attribute it to 5A1MQ over the deficit. My methylation markers (SAM/SAH) didn't meaningfully move.
45 posts
If you're going to run it, DEXA before and after, measure waist weekly. Otherwise you'll convince yourself it worked when the deficit was doing the work.
34 posts
Small molecule, oral, mouse data only, sold as a supplement — that's the profile of three dozen failed compounds. Not saying this one's fake, saying the genre has a bad track record.