Cagrilintide — anyone running it and what outcomes

Ran cagri 2.4mg weekly for 12 weeks. -4.8kg, slow and steady. Different feel than GLP-1 — less nausea, more satiety after meals, slower gastric emptying is noticeable.

Cagri alone at 2.4mg is ~60% of GLP-1 mono-efficacy in my observation. The combo with sema is where cagri earns its keep.

Cagri's mechanism (amylin) is complementary to GLP-1. Combined therapy has shown additive effects in trials. Worth the extra compound if you're hitting a GLP-1 plateau.

Haven't tried. Keeping an eye on the combo data from the sema/cagri trials.

Cagri + sema combo at low doses was smoother than sema up-titrated alone for me. Less nausea per kg lost. Worth considering if sema side effects are the blocker.

Ran cagri alone for 16 weeks, -6.1kg. Slow but extremely tolerable. For people who can't handle GLP-1 nausea, this is the option.

Cagri solo is honestly kinda weak if you've got any tolerance to GLP-1s already. The amylin angle is real but it's not a replacement, it's an add-on. If you're looking to break through a plateau the combo makes sense, but don't sleep on just pushing sema dose higher first. Seen way more people get solid results that way than introducing another compound into the mix.

yeah cagri solo felt like spinning wheels for me. stacked it with low dose sema and thats when shit actually moved. the combo thing is legit if youre already familiar with glp-1 sides