Cagrilintide — anyone running it and what outcomes

Ran cagri 2.4mg weekly for 12 weeks. -4.8kg, slow and steady. Different feel than GLP-1 — less nausea, more satiety after meals, slower gastric emptying is noticeable.

Cagri alone at 2.4mg is ~60% of GLP-1 mono-efficacy in my observation. The combo with sema is where cagri earns its keep.

Cagri's mechanism (amylin) is complementary to GLP-1. Combined therapy has shown additive effects in trials. Worth the extra compound if you're hitting a GLP-1 plateau.

Haven't tried. Keeping an eye on the combo data from the sema/cagri trials.

Cagri + sema combo at low doses was smoother than sema up-titrated alone for me. Less nausea per kg lost. Worth considering if sema side effects are the blocker.

Ran cagri alone for 16 weeks, -6.1kg. Slow but extremely tolerable. For people who can't handle GLP-1 nausea, this is the option.