Lean mass preservation on tirze — it's more aggressive than sema, is protein enough?

Same protein target (1g/lb goal weight). The lever that should change is training volume, not protein. Faster weight loss = harder recovery = reduce total sets, not increase them. But absolutely maintain the protein floor. Protein need is dose-of-deficit, not dose-of-drug.

@nopain_noreign this is the correct answer. 'Eat more protein' is a floor, but the ceiling on lean preservation is controlled by deficit size. You cannot out-protein a 1500 kcal deficit.

Cap rate of loss to manage lean preservation. If you're dropping >1.5% bw/week sustained, your body is going to take some of that from muscle regardless of protein. Slow the drug or raise calories until you're back under 1%. That's the real protection, not more scoops of whey.

Pulled my serial DEXA data — LBM loss scales with weekly rate of total loss much more than with absolute protein intake (everyone I'm comparing was 0.9g+ per lb goal). People losing 2lb+/wk on tirze lost 22-30% of that as lean. People losing 1lb/wk lost 10-15% as lean. Rate is the lever.

Creatine 5g, protein 0.9g/lb goal weight, resistance train 2-3x/wk, cap loss at 1% bw/week. That's the non-negotiable protocol on any GLP-1. Everything else is optimization.

Add: don't drop training weight. Most people on fast loss drop their working sets by 20-30% because they 'feel weak.' If you can still rep the same weight, rep it — preserving strength preserves neurological drive and protects against muscle atrophy even when calories are tight.

What's 1% bw/week actually look like for a 250lb person?

@wanderlite 2.5lb/wk, ~10lb/mo. That's the upper bound you want. Above that and lean mass loss accelerates. Below that for most people is sustainable.