DSIP for sleep — who's actually gotten something out of this
32 posts
Delta sleep-inducing peptide (DSIP) has been on the fringe of the sleep compound conversation for decades. The human literature is mostly old Russian and European work, and modern trials are basically non-existent. But every few months a new thread asks 'does DSIP work for sleep?' and the answers are all over the map.
My honest experience after 6 weeks at 100mcg sub-q 30 minutes before bed:
- Deep sleep (measured by Oura, which is imperfect) up modestly from baseline — maybe 10–15 min average
- Subjective sleep quality: better the nights I took it, but not dramatically
- No morning grogginess, no dependency, no weird dreams
- Stopped for 2 weeks: sleep regressed to baseline
- Restarted: benefit returned
For me, file it under 'real but modest.' It's not ambien. It's not even really 'sedating.' It's more like it makes the sleep you're already having a little deeper.
Who else has run this long enough to have an opinion? Specifically interested in people who tracked it with something objective (sleep study, Oura, Whoop) rather than pure vibes.
18 Replies
18 posts
Ran DSIP 100mcg nightly for 12 weeks with an Oura. Effect is real but small. Deep sleep +8 min on average, REM basically unchanged, total sleep +15 min. Subjective quality was the bigger win — I just felt more rested. Placebo possible but the washouts were persuasive.
31 posts
I stack DSIP with low-dose melatonin (300mcg) and magnesium glycinate. The combo works better than any component alone. DSIP on its own was just okay for me.
205 posts
DSIP is one of those compounds where if you came in expecting a benzo you'll be disappointed, and if you came in expecting nothing you'll be mildly surprised. It's subtle.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 500 mcg · 2x/day · sub-Q
16 posts
'Real but modest' is the honest answer for 90% of peptides. DSIP is no different. The 'I slept like a baby!' posts usually come from people on week 1 who haven't controlled for novelty.
58 posts
The mechanism isn't well-understood which makes dose and timing kind of guesswork. Most people converge on 100–200mcg 30–60 min pre-sleep, sub-q. I wouldn't go higher — there's no indication more is better.
- Epithalon · 10 mg · 10d on / 80d off · sub-Q
- MOTS-c · 5 mg · 2x/wk · sub-Q
- 5-Amino-1MQ · 150 mg · daily · oral
22 posts
12 weeks, 150mcg. Deep sleep up, HRV up 4-5ms. Discontinued due to cost, sleep regressed by about the same amount. I'd run it again if it were cheaper.
119 posts
The age of the literature is a yellow flag, not a red one. A lot of good old Russian and German pharmacology never got replicated in modern Western trials because of funding priorities, not because the original work was wrong. Can't tell for sure which of the 'lost peptides' are real vs forgotten for good reason.
36 posts
DSIP fits into my longevity stack as a 'low cost, small benefit, low risk' adjunct. Not a headliner. I run it 5/2 with weekends off, 100mcg.
71 posts
What would convince me: a modern n=30+ crossover trial with polysomnography endpoints. We don't have that. Everything is self-reported or wearable-based. Which doesn't mean it's fake, just means we're still guessing on magnitude.
115 posts
Agree with citation_required. DSIP is in the category of 'plausibly effective, under-studied, probably safe at community doses, probably not a game-changer.' Which describes half the compounds on this forum.
2 posts
I tried it for a month and got nothing. But my sleep was already 90th percentile. Possible ceiling effect.
7 posts
Running DSIP for jetlag resets (monthly international travel). For that use case specifically it's been the best tool I've tried, beats melatonin for me. YMMV.
94 posts
The jetlag use case @reclusive_rn mentions is interesting and I haven't seen it discussed. Might be the strongest argument for keeping DSIP on hand.
- CJC-1295 no DAC · 100 mcg · pre-bed · sub-Q
- Ipamorelin · 200 mcg · pre-bed · sub-Q
- BPC-157 · 250 mcg · 2x/day · sub-Q
17 posts
5 posts