Reta vs tirze — 16 weeks in, the efficacy jump is not subtle

You said HR up 6bpm — resting or average? And did you track BP? The GCG arm should be doing some cardiovascular stuff and that's the part I watch.

The 'forget to eat' vs 'food stops being interesting' distinction is real. I ran tirze for 14 months and that's exactly how I'd describe it. Interested to hear the plateau experience at higher reta doses, because that's where I expect the divergence to show.

This is the first report I've read where someone actually did the tirze-then-reta comparison with numbers rather than 'reta hits harder bro.' Saving.

The thermogenic report tracks with GCG receptor activation — glucagon increases resting energy expenditure in every study that measured it. Not pattern matching. You're feeling the mechanism.

Want to temper this — the phase 2 trial showed ~24% weight loss at 48 weeks on 12mg. That's ceiling data, not 8-week extrapolation. You may be ahead of schedule because your body already adapted to incretin receptor activation from a year on tirze. Different starting point.

@plateau_breaker resting from Oura, averaged over baseline month vs current. BP went from 118/74 to 122/78. Not alarmed yet but watching. I'll draw a full CMP + lipids at week 12 to see what else moved.

@macrosguru 180g protein minimum. I meal-replace with whey + casein blend when solid food isn't happening. It's the non-negotiable of this protocol for me.

@showmethestudy fair and I don't think I'll hold this pace. My expectation is the next 8 weeks are 8-10lb, not 19. Going in eyes open.

Protein intake during this? The thing I worry about on reta particularly is lean mass preservation when appetite is suppressed hard enough that you forget to eat.

@cyclecraft yes. For GLP-naive I'd say 4 weeks at 2mg, 4 at 4mg, then evaluate. The 2-week jumps are because I already had the machinery tuned from tirze. Naive people will puke.

Would you titrate the same way for someone who hasn't done tirze first? I suspect a GLP-naive person needs to crawl 2 → 4 slower.

Interesting that the GI settled on 8 but was rough on the 6 jump. My theory — and I've seen this on sema and tirze — is the GI is worst at the first exposure to that dose and your body adapts at each step. So the 6mg jump was your body meeting the new ceiling, and 8 is just incremental.

The cardiovascular point is the one the board hasn't caught up on yet. Reta's GCG arm is novel territory — the trials haven't fully characterized long-term BP/HR trajectories in non-diabetic weight loss populations. Draw bloods. Track HR trend. Don't fly blind.

19lb in 8 weeks is bananas honestly. Even for someone with tirze tolerance baked in. I did 9lb in 8 weeks on sema at comparable starting weight.

Following. Subscribed. Drop the week 12 bloodwork post please.

One report, one subject, no control for diet changes during switch, heavy prior incretin exposure. Useful n=1 but do not generalize efficacy from this.

DEXA at 0/8/16? If not now, please start. This is the exact data the community needs and you're in a good position to capture it.

@dexa_devotee booked one for week 12. Didn't get a week 0 unfortunately but have a DEXA from 11 months ago as a rough reference.